Most types of dementia are nonreversible (degenerative). Nonreversible means the changes in the brain that are causing the dementia cannot be stopped or turned back. Alzheimer's disease is the most common type of dementia.
Lewy body disease is a leading cause of dementia in elderly adults. People with this condition have abnormal protein structures in certain areas of the brain.
Dementia also can be due to many small strokes. This is called vascular dementia.
The following medical conditions also can lead to dementia:
Use of certain medications, including cimetidine and some cholesterol-lowering medications
Dementia usually occurs in older age. It is rare in people under age 60. The risk for dementia increases as a person gets older.
Symptoms
Dementia symptoms include difficulty with many areas of mental function, including:
Language
Memory
Perception
Emotional behavior or personality
Cognitive skills (such as calculation, abstract thinking, or judgment)
Dementia usually first appears as forgetfulness.
Mild cognitive impairment is the stage between normal forgetfulness due to aging and the development of dementia. People with MCI have mild problems with thinking and memory that do not interfere with everyday activities. They are often aware of the forgetfulness. Not everyone with MCI develops dementia.
Symptoms of MCI include:
Difficulty performing more than one task at a time
Difficulty solving problems or making decisions
Forgetting recent events or conversations
Taking longer to perform more difficult mental activities
The early symptoms of dementia can include:
Difficulty performing tasks that take some thought, but that used to come easily, such as balancing a checkbook, playing games (such as bridge), and learning new information or routines
Getting lost on familiar routes
Language problems, such as trouble finding the name of familiar objects
Losing interest in things you previously enjoyed, flat mood
Misplacing items
Personality changes and loss of social skills, which can lead to inappropriate behaviors
As the dementia becomes worse, symptoms are more obvious and interfere with the ability to take care of yourself. The symptoms may include:
Change in sleep patterns, often waking up at night
Difficulty doing basic tasks, such as preparing meals, choosing proper clothing, or driving
Forgetting details about current events
Forgetting events in your own life history, losing awareness of who you are
Having hallucinations, arguments, striking out, and violent behavior
Having delusions, depression, agitation
More difficulty reading or writing
Poor judgment and loss of ability to recognize danger
Using the wrong word, not pronouncing words correctly, speaking in confusing sentences
Withdrawing from social contact
People with severe dementia can no longer:
Perform basic activities of daily living, such as eating, dressing, and bathing
Medications may be needed to control behavior problems caused by a loss of judgment, increased impulsivity, and confusion. Possible medications include:
Certain drugs may be used to slow the rate at which symptoms worsen. The benefit from these drugs is often small, and patients and their families may not always notice much of a change.
Donepezil (Aricept), rivastigmine (Exelon), galantamine (Razadyne, formerly called Reminyl)
Memantine (Namenda)
A person's eyes and ears should be checked regularly. Hearing aids, glasses, or cataract surgery may be needed.
Psychotherapy or group therapy usually does not help because it may cause more confusion.
For information on how to take care of a loved one with dementia, see: Dementia - home care
Expectations (prognosis)
People with mild cognitive impairment do not always develop dementia. However, when dementia does occur, it usually gets worse and often decreases quality of life and lifespan.
Complications
Complications depend on the cause of the dementia, but may include the following:
Abuse by an overstressed caregiver
Increased infections anywhere in the body
Loss of ability to function or care for self
Loss of ability to interact
Reduced lifespan
Side effects of medications used to treat the disorder
The condition of a person with dementia gets worse
You are unable to care for a person with dementia at home
Prevention
Most causes of dementia are not preventable.
Quitting smoking and controlling high blood pressure and diabetes can help you reduce your risk of vascular dementia. This is dementia caused by a series of small strokes. Eating a low-fat diet and exercising regularly may also reduce the risk of vascular dementia.
References
Burns A, Iliffe S. Alzheimer's disease. BMJ. 2009;338.
DeKosky ST, Kaufer DI, Hamilton RL, Wolk DA, Lopez OL. The dementias. In: Bradley WG, Daroff RB, Fenichel GM, Jankovic J, eds. Bradley: Neurology in Clinical Practice. 5th ed. Philadelphia, Pa: Butterworth-Heinemann Elsevier; 2008:chap 70.
Knopman DS. Alzheimer’s disease and other dementias. In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 409.
Peterson RC. Clinical practice. Mild cognitive impairment. N Engl J Med 2011 Jun 9;364(23):2227-2234.
Qaseem A, et al., American College of Physicians/American Academy of Family Physicians Panel on Dementia. Current pharmacologic treatment of dementia: a clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians. Ann Intern Med 2008 Mar 4;148(5):370-8.
Review Date:
9/26/2011
Reviewed By:
Luc Jasmin, MD, PhD, Department of Neurosurgery at Cedars-Sinai Medical Center, Los Angeles, and Department of Anatomy at UCSF, San Francisco, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
Print
E-mail
